The existing study didn’t reflect the seroprevalence of Covid 19 antibodies in children significantly less than 18 years as this group was excluded from the analysis. In conclusion, the entire prevalence of COVID 19 antibody in the overall population from the Southern Andaman district was 39.3% that was comparatively higher to seroprevalence conducted in all of those other nation. The seroprevalence of Covid 19 in the S. Andaman area was found to become 39.3%. The COVID 19 antibody positivity was considerably higher in metropolitan inhabitants (44.09%) when compared with rural inhabitants (34.27%) and in females of 41C60 years generation (45.5%) when compared with females of other age ranges. The antibody positivity was similar among the populace of buffer and containment zone (p-value 0.684). Summary The seropositivity in the South Andaman area was higher because of the influx of vacationers on the isle. The rural people in South Andaman continued to be less suffering from the pandemic as the rural areas had been significantly flung and thinly filled. The antibody positivity was identical in occupants of containment and buffer area because there have been more social connections and movement from the people for the isle because of the extensive family members linkage. Keywords: Andaman, Covid 19, 1st influx, Immunity, Serosurvey 1.?Intro Coronavirus disease 2019 (COVID-19) offers emerged like a pandemic, as well as the infection offers spread to a lot more than 200 countries right now.1 Global data shows that a significant percentage of SARS-CoV-2 attacks are asymptomatic and remain undetected unless populations are actively screened.2 , 3 Facility-based surveillance efforts will probably miss asymptomatic and mild instances. The household-based antibody serosurveillance can decrease the selection biases of medical center and laboratory-based tests. The household-based antibody serosurveillance might help the medical community in producing evidence concerning the part of asymptomatic disease in the transmitting of Covid 19 and estimation of degree of this disease locally.4 , 5 Indian Council of Medical Study (ICMR) first circular of serosurvey in MayCJune 2020 discovered that Seropositivity of SARS-CoV-2 was 0.73% in India, in August 2020 discovered that Seroprevalence of SARS-CoV-2 was 6 2nd circular of ICMR serosurvey.6% in India.6 , 7 The seroprevalence in other areas of India varied from 24.08% to 51.5%.8.9 Thus, there is a PLX8394 whole lot of geographical and temporal variation in the prevalence PLX8394 of Covid 19 antibodies among different states in the united states.6, 7, 8, 9, 10, 11 None of the scholarly research covered Andaman and Nicobar islands. The area of South Andaman, among the three Districts of Andaman & Nicobar Islands, is situated in between longitude E 92 to E 94′ and latitude N 6′ to N 14′ in the Bay of Bengal Area. The Total Section of the South Andaman Area can be 2980 Sq. Kilometres. South Andaman includes PLX8394 a combination of wealthy beaches, increasing hinterland, and thick equatorial forests rendering it a preferred visitor destination of India. This area has a inhabitants denseness of 80 per sq Kilometres only which can be far less compared to the Indian typical of 324 individuals per sq. kilometres. South Andaman area includes a exclusive feature of geography and inhabitants of its. Therefore, today’s study was completed to estimation the prevalence of Coivd 19 antibodies in the South Andaman Area and to discover the setting of pass on of Covid 19 locally in the South Andaman Area. The analysis also attempted to measure the Covid 19 antibody level over the inhabitants surviving in the containment and buffer area of South Andaman area as this may reveal the amount of exposure as well as the immunity PLX8394 of UPA the city. 2.?Technique and Components A community-based cross-sectional seroprevalence research was conducted in the South Andaman area. South Andaman may be the most filled area of Nicobar and Andaman Isle, an archipelago in the Bay of Bengal. The three districts of Nicobar and Andaman Island are separated simply by sea and challenging terrains. Hence, the South Andaman area comes with an nearly isolated and segregated inhabitants of 238,142 (2011 census). The scholarly study was conducted in the populace above 18 years surviving in South Andaman Area. The kids significantly less than 18 years had been excluded from the analysis since they had been shielded from viral publicity as the institutions and colleges had been closed for a lot more than nine weeks due to regular lockdowns. The individuals experiencing any immune-deficient condition or under chemotherapy were excluded through the scholarly research. To be able to support the pass on of disease in the area, the area administration of South Andaman area specified containment and buffer area in the area based on the requirements laid down by the federal government of India.12 The containment areas were identified from the rapid response group predicated on the degree of cases listed and mapped by them. If contact mapping and listing took a lot more than 24? h to complete the complete part of 3 after that?km radius encircling the epicenter (home from the positive case) in.