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?(Fig.2D2D and E). These ramifications of acrolein had been reproduced by TRPV4 agonists and avoided by antioxidant NAC considerably, p38 inhibitor SB203580, TRPV4 antagonist RN\1734, and CBX. Additional research showed that CBX suppressed TRPV4 agonist\initiated calcium influx and following cell injury potently. CBX attenuated CYP\induced