While advances in pharmacologic options for HIV treatment have reduced the incidence and severity of ART-induced adipocyte toxicity (principally mitochondrial DNA [mtDNA] depletion and altered gene expression), the persistence of viral proteins in circulation and locally within adipose tissue impairs adipocyte maturation and activity despite suppression of plasma viremia on therapy (2, 7, 29, 57, 163, 186, 196, 236, 260)

While advances in pharmacologic options for HIV treatment have reduced the incidence and severity of ART-induced adipocyte toxicity (principally mitochondrial DNA [mtDNA] depletion and altered gene expression), the persistence of viral proteins in circulation and locally within adipose tissue impairs adipocyte maturation and activity despite suppression of plasma viremia on therapy (2, 7, 29, 57, 163, 186, 196, 236, 260)

While advances in pharmacologic options for HIV treatment have reduced the incidence and severity of ART-induced adipocyte toxicity (principally mitochondrial DNA [mtDNA] depletion and altered gene expression), the persistence of viral proteins in circulation and locally within adipose tissue impairs adipocyte maturation and activity despite